News

Article

14 September 2023

Redaction: C. Cebo - Edition P. Huan - W Brand-Williams

An International Research Network between France and Quebec involving several GABI teams is underway.

The objectives of the project are to promote exchanges between scientists and favor the mobility of researchers and students working on important research subjects.
Article

14 September 2023

Redaction: F. Calenge - Edition P. Huan - W Brand-Williams

Retired veterinarians from the Lyon Veterinary School visit GABI : the GeMS team presents their work on the intestinal micriota in farm animals.

On Friday September 20th, the INRA Jouy-en-Josas research center hosted a groupe of retired veterinarians from the Lyon Veterinary School. Two scientists belonging to GABI's GeMS team, Marion Borey and Fanny Calenge presented their work on the importance of studying the intestinal microbiota in farm animals.
Photo (de gauche à droite) : MS Lund, B Guldbrandtsen, G Sahana (encadrant principal), M Uddin, CB Jorgensen (rapporteur), J Jensen (président), G Andersson (rapporteur), D Boichard
Article

14 September 2023

Redaction: D. Boichard - Edition P. Huan - translation D Boichard/ W Brand-Williams

Mohammed Mesbah Uddin defended his PhD dissertation at Aarhus University, Denmalrk on September 17, 2019.

This thesis was focused on a complex trait for genetic improvement in cattle due to its low heritability but its strong variability, and its opposition with dairy production. Mesbah's work was aimed at identifying causal genetic variants implicated in femal fertility determinism using different approaches.
Article

09 October 2023

Redaction: GABI Equipe G2B - Edition P. Huan - W. Brand-Williams

A new research highlight: "Genetic determinism for cheese-making ability of milk."

Prediction equations for cheese-making abilities using Middle-Infrared spectra of milk were developed and applied to several million spectra in the Monbeliard bovine breed. A genetic analysis shows that coagulation parameters and yield are heritable. An association analysis on the whole genome sequence level identified 59 QTL and a network of 736 co-regulated genes.
Article

14 September 2023

Redaction: M. Tixier-Boichard - Edition P. Huan - W. Brand-Williams

What is chocolat plumage in the domestic chicken ?

Chicken plumage presents many genetically determined color variations. Chocolate plumage is characterized by a brown-chocolate color that replaces black in animals that carry the 'choc' mutation, described since 1996 as recessive and sex-associated. Seeral domestic mammals and in the quail, mutations for the gene coding for the Tyrosinase Related Protein 1 enzyme have been associated to colors such as 'havane', 'red' or 'brown'.
Article

05 October 2023

Redaction: Web - Edition P. Huan - translation W. Brand-Williams

The experimental farm, the "Pin" (61310 le Pin-au-Haras) hosts the "Prairiales" seminar on Thursday June 13..

A seminar involving both scientists and breeders/professionals in animal breeding. Many INRA scientists (Animal Genetics, Livestock Production and Animal Health Divisions notably) will present their work to breeders.
GABI: Animal Genetics and Integrative Biology unit
Article

05 October 2023

Redaction: D. Rocha - Edition P. Huan - Translation W. Brand-Williams

A study of allele-specific expression in catle published in Scientific Reports

Scientists sequenced genomes and complete transcriptomes in these animals and they identified 5 658 Single Nucleotide Polymorphisms (SNP) showing a biais for allele expression in 13% of the expressed genes.
Article

05 October 2023

Redaction: Service presse INRA - Edition P. Huan - Translation W. Brand-WIlliams

Creation of the INRA/BAIF Associated International Laboratory (LIA), GIMIC "Genetic IMprovement of Indian Cattle and Buffaloes"

Inra in India: a new LIA reinforces our research partnership with the BAIF for rural, environmental and food security development.
INRA, V. Ducroq
Article

05 October 2023

Redaction: GABI Equipe G2B - Edition P. Huan - Translation W. Brand-Williams

Creation of an Internationally Associated Laboratory GIMIC (Genetic IMprovement of Indian Cattle and buffaloes) between GABI and an Indian NGO, the BAIF.

The Internationally Associated Laboratory GIMIC was created in 2018 for five years. It coordinates the activties of a large Indian NGO, the BAIF, and a group of geneticists and professors from AgroParisTech, all members of the research unit GABI. GIMIC will explore the use of modern tools such as genomic selection for genetic improvement of taurine x zebus crossbred animals and buffaloes in a tropical environment on small farms.
A. Duchesne, INRA,
Article

05 October 2023

Redaction: A. Duchesne - Edition P. Huan - W. Brand-Williams

Mutation of the gene KIF1C : a test for screening and eradicating progressive ataxia in the bovine Charolais breed, but also a natural model for the study of the demyelinating diseases in man

Progressive ataxia is a neurodegenerative anomaly described in Charolais cattle since 1972. This disease affects the welfare of affected aniamls and is expensive for breeding because of its late expression. The mutation responsible was identified in the gene KIF1C .A partnership with the Institut du Cerveau et de la moelle épinière (The Brain and Spinal Cord Institute) has made it possible to exploit this bovine model to advance in the understanding of the pathophysiology of these anomalies.
FAANG, European Community
Article

14 September 2023

Redaction: GABI Equipe GIS - Edition P. Huan - Translation W. Brand-Williams

The FAANG action is on the rise!

The FAANG initiative (Functionnal Annotation of Animal Genomes) was formally launched at the beginning of 2015. Since then, the initiative has been widened to research activities undertaken by an increasing number of international partners. INRA was and remains one of the central partners of this consortium. FAANG has now entered a phase of growth in which annotation efforts will be led at a larger scale for the study of several scientific questions, with the ultimate goal of unveiling the fine mechanisms of genome regulation in order to associate the genotype and phenotype and therefore better exploit genetic and epigenetic variability. This review, requested by the journal "Annual Review of Animal Biosciences" was aimed at evaluating the results acquired by FAANG and tracing the future directions of this initiative.
Article

05 October 2023

Redaction: GABI Equipe GENAQUA - Edition P. Huan - Translation W. Brand-Williams

Aquakultor, the first video game for a smarphone in which the player becomes a fish breeder!

Aquaculture production increases every year and it must meet sustainability challenges. Mathieu Besson's PhD studies (in partnership with Wageningen university and INRA, Rennes) have shown that genetic selection can improve the economic results of fish farms and reduce their impact on the environment.
Article

05 October 2023

Redaction: GABI G2B team - Edition P. Huan - Translation W. Brand-Williams

Genetic determinism of body size in cattle

As part of the "1000 bovine genome" consortium, scientists from INRA and Allice and their partners abroad have explored the genetic determinism of animal stature, showing its complexity. At least 163 genomic regions are implicated in the genetic control of cattle size, but they only explain 14% of the variability of this trait in the populations studied. This complex genetic determinism is similar to what is observed in man for which the genes identified as being implicated only explain 10 to 20% of the observed variability.
Article

05 October 2023

Redaction: GABI G2B team - Edition P. Huan - Translation W. Brand-Williams

INRA an actor in the application of the European Zootechnical Rules

The 2016/2020 European Zootechnical Rules became effective on November 1, 2018. These rules modify the structure of animal selection. This provision cancels out INRA's regularory role in carrying out evaluations.
Article

14 September 2023

Redaction: GABI Equipe G2B - Edition P. Huan - Translation W. Brand-Williams

Identification of two mutations responsible for embryo death in the Holstein breed

The development of bovine genomic selection has produced a large number of genotypings. Using this database, haplotypes presenting an important deficit in homozygotes were identified with increasing strength. It also allows testing candidate mutations shown after sequencing and with good annotation information. These two approaches allowed the identification of two ideal mutations in the homozygous state in SDE2 and CENPU genes.
Article

14 September 2023

Redaction: Y. Ramayo-Caldas, D. Rocha - Edition P. Huan - W. Brand-Williams

Signatures of selection in Cuban Charolais cattle

The charolais cattle imported to Cuba at the beginning of the XXth century are an interesting model for the study of heat adaptation. Studies on genetic diversity have shown 104 regions of the genome that differenciate Cuban charolais cattle, in which the genes implicated in disease resistance, physiological changes and heat tolerance figure along with that for muscle development. These studies, led by a multidisciplinary group of Cuban, French and Spanish scientists, provide information to help us understand the biological processes associated with adaptation of cattle to tropical conditions.
Article

05 October 2023

Redaction: PHuan - W Brand-Williams (translation)

Deep Learning and Genomics Workshop: the speakers' presentations are now available

This subject is particularly important to the scientific community; nearly two hundred participants from different fields were reunited (MDs, biologists, bioinformaticians and statisticians).
Article

14 September 2023

Redaction: Florence Jaffrézic et Denis Laloë (PSGen) - Edition P. Huan

The workshop PREDICT Psay-CompBio

Several subjects were treated on the “Integration of heterogenous and high-throughput data for the identification of predictive biomarkers”.
Article

14 September 2023

Redaction: Service Presse Inra - Edition P. Huan - W. Brand-Williams

"Top model" cows for research

The cow may be a relevant model for the study of human genetic disorders. This is the conclusion drawn by an international team led by the INRA in partnership with ALLICE, the CEA and VetAgroSup for France - published in the journal Scientific Reports. In cattle, the study of the mutations responsable for rare syndromes, which are also observed in men, provide an interesting alternative to laboratory animals to confirm the genetic origin of these diseases and determine the underlying molecular mechanisms.
Article

14 September 2023

Redaction: E. Barrey - Edition P. Huan

Our GWAS revealed that equine performance during endurance races is a complex polygenic trait, and is partially governed by at least five QTL

Endurance horses are able to run at more than 20 km/h for 160 km (in bouts of 30 to 40 km). This level of performance is based on intense aerobic metabolism, effective body heat dissipation and the ability to endure long exercise.
Article

14 September 2023

Redaction: Inra

New knowledge on animal awareness

Do animals have emotions? Do they have a life history? Following a request made by the European Food Safety Authority (EFSA), the INRA organised a collective scientific assessment on animal awareness. The results were presented to representatives of European member countries belonging to the animal welfare network, the EFSA and the European Commission on 11 and 12 May, 2017 in Parme, Italy.