This project will contribute to establishing clear guidelines for the simulation of realistic hologenomic data, the construction of microbiota-based similarity matrices, and the optimal combination of genomic, microbiota, and multi-omics data in a wide variety of scenarios.
Her PhD project englobes a research project at the interface of different fields of study, since it is applied to a current biological question raised at INRAE concerning bull fertility. Her presentation was focused on copula methods for network inference of multi-omics regulation.
The FarmGenomic project is aimed at exploring "How the high-throughput genomic era can be used to answer our questions on the evolution of chickens?".
Her PhD dissertation entitled "The mammary gland: Role of SOCS2 in its development and impact of inflammation during successive lactations" was carried out under the supervision of Fabienne Le Provost within the GABI unit.
More than 250 positions are available now on the INRAE Jobs web site! Discover all the positions available and apply on-line. If you do not have the degree required to apply, you may request an equivalence. Discover the profiles open to join one of GABI's teams!
You would like to contribue to public research, to get involved in projects important for society's challenges ? Join our research teams by enrolling in one of our Open competitions for a Junior Research Position (men/women) : applications open up to March 2, 2023!
Our future is being written now!
Would you like to join INRAE at GABI and enjoy living in France? Send your application to join the international and dynamic team of EuroFAANG!
EuroFAANG is a European Infrastructure project (HORIZON-INFRA-2022-DEV-01 Research Infrastructure Concept Development) coordinated by the Research Institute for Farm Animal Biology (FBN, Germany) that will start in January 2023 and run until December 2025. We are seeking a dynamic and self-motivated Assistant Research Manager.
Fish are exposed to large variations in the concentration of oxygen in their aquatic environment. When oxygen is depleted in relation to what is needed to maintain the energy metabolism of fish, this is called hypoxia. Hypoxia is one of the major threats to the aquaculture sector, causing substantial economic losses for fish farmers. It can strongly affect the health and welfare of fish, impacting on growth, reproduction, behaviour, immunity and other energy-demanding activities. Thus, improving hypoxia tolerance is of great economic and ethical interest to be included in aquaculture breeding programmes.
Among the anomalies reported to the Observatoire National des Anomalies Bovines (ONAB, www.onab.fr), a form of cleft palate emerged in 2012 in Limousine cattle. The animals have a total cleft palate involving the bony palate and the muscular palate. In the majority of cases, no other clinical signs are associated with cleft palate. Nevertheless, the survival of the animals and their well-being are largely compromised by this anomaly.
The ongoing COVID-19 pandemic continues to pose a need for new and efficient therapeutic strategies. We explored antisense therapy using oligonucleotides targeting the severe acute responiratory syndrome (SARS-CoV-2). We are pleased to annouce the publication of this collaborative study involving GABI, the VIM Unit and The University Andres Bello (Santiago, Chili) on the experimental demonstration of active Antisens Oligonucleotide activity on the in vitro inhibition of SARS-CoV-2 virus replication, the virus responsible for COVID-19.
While fishing has reached its limits, the demand for fish is increasing every year. In this context, aquaculture constitutes an alternative, provided that it is sustainable while allowing a quality production. INRAE, the Aqualande group and its trout selection and reproduction company "les Sources de l'Avance", and the Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF) have carried out a review of a 20-year rainbow trout selection program conducted by the company. They compared the growth and feed requirements of trout from this program with those of non-selected trout. Their results, published in Aquaculture Reports, show that 17 to 20 percent less feed is now required for the same growth of the fish with the selected trout, thus reducing the environmental impact. A locally produced sustainable feed, without fish oil, fish meal or soy, was also tested on both groups of fish. Growth gains and nutritional qualities are maintained with this feed of the future. This original work on a global scale shows that genetic improvement and innovative feed development can be effectively combined to contribute to a more sustainable aquaculture.
Multiple, complex, overlapping annotations.... You are wondering how is the best way to use them in your genomic prediction model? The BayesRCO open software is what you need! In the H2020 GENE-SWitCH project, scientists from GABI have developed two new Genomic Evaluation (GE) Bayesian models (BayesRCπ et BayesRC+) to improve assoications between genotypes and quantitative phenotypes while managing complex annotations.
You will be welcomed within the UMR GABI on the INRAE site of Jouy-en-Josas,20 km south-west from Paris, in the Genetics in aquaculture team (GenAqua) which develops work concerning the genetic improvement of fish and bee species. Your project will be part of the broader framework of the “CoBreeding” project of the national research program “PEPR Agro-Ecology and Digital”, bringing together more than 80 researchers from animal and plant sciences. In this context, your work will be based on two animal species, the rainbow trout and the laying hen, whose uniqueness compared to other animal species is that they are reared in very large groups of several hundred to thousands of individuals within the same batch. The work will be carried out in close collaboration with the teams working in poultry genetics from the PEGASE unit (Rennes) and the GABI unit (Gibbs team).
Each year, the French Academy of Agriculture awards two prizes during its annual meeting in September. This year, two scientists from GABI were recognized for their work: the GOLD MEDAL was awarded to Michèle Tixier-Boichard and the Silver-Dufrenoy medal to Ronan Griot, for his work during his PhD. The award ceremony was held on September 21st, 2022. Congratulations to them both!
At the Council Meeting, held in Paris on August 9, 2022, during the XXVI World’s Poultry Conference, the position of President of the World’s Poultry Science Association was officially passed from Pr Ning Yang of China to Dr Michèle Tixier-Boichard from France.
This research theme aims to gather knowledge on the role of non-coding RNAs (ncRNAs) that participate in the communication pathways between mitochondria and the cell. This special issue of Frontiers in Physiology presents unique research focused on mitochondria-associated ncRNAs as well as original papers demonstrating the therapeutic potential of certain RNAs. BIGE researchers are actively involved in the scientific work in this area.
The knowledge of the variations of the DNA sequence which constitutes the genome of an individual is a central information in genetic research. If it is possible to sequence the entire genome to know all these variations, it remains very expensive. Genotyping chips, which are much less expensive, make it possible to work with an intermediate density of information (corresponding to a selection of positions, or "markers", judiciously distributed over the genome). However, their efficiency is directly related to the number of available markers. For rainbow trout, the leading farmed fish species in France, INRAE and its partners have just developed a new high-density genotyping chip (665,000 markers, i.e. about 15 times more than the best tools available so far), which greatly increases the analysis power obtained. By providing access to much more precise genomic information, this chip will make it easier to identify the genes responsible for differences between individuals and to develop more effective selection procedures to adapt animals to changing environmental conditions.
Vaccination of livestock is one of the most effective ways to prevent infectious diseases. The links between vaccine response and variations in the gut microbiota are poorly studied, yet the latter plays a considerable role in the regulation of immunity. In addition, it has been established that genetic variations in hens can influence the composition of the microbiota and the vaccine response.
You are an INRAE employee or, more generally, a civil servant or have a permanent contract under public law in one of the three civil services (with at least 3 years' seniority). Do you want to evolve in your missions and take up new challenges? With us, you will develop useful and beautiful research projects.
A profound transformation of agricultural production methods has become unavoidable due to the increase in the world’s population, and environmental and climatic challenges. Agroecology is now recognized as a challenging model for agricultural systems, promoting their diversification and adaptation to environmental and socio-economic contexts, with consequences for the entire agri-food system and the development of rural and urban areas. Through a prospective exercise performed at a large interdisciplinary institute, INRAE, a research agenda for agroecology was built that filled a gap through its ambition and interdisciplinarity.