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INRAE B. Nicolas (Manipulation sous hotte aspirante)
Article

05 October 2023

Redaction: Edition P. Huan

A new functional assay for the analysis of splice variants in the bovine DGAT1 gene

The DGAT1 gene plays a major role in fat metabolism and triacylglyceride synthesis.
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GABI: Animal Genetics and Integrative Biology unit
Article

14 September 2023

Redaction: INRAE - Edition P. Huan

A new genetic lead to stem the spread of nodavirosis, the most widespread disease in sea bass farming

Teams from Ifremer and INRAE have just discovered two genes involved in resistance to nodavirosis, a disease that affects the brain of sea bass and causes major losses in Mediterranean fish farms. Following this discovery, published in the journal Genetics Selection Evolution, scientists and professionals from French sea bass hatcheries, which supply over 20% of the sea bass farmed in the Mediterranean (Italy, Greece, Turkey...), have launched a new project to select sea bass that are more resistant to this disease. This is a major challenge if we are to move towards more sustainable aquaculture.
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INRAE, Auteur Nicolas Bertrand (bassin de truites en pisciculture)
Article

05 October 2023

Redaction: Edition P. Huan

Phenotyping isogenic trout lines to elucidate mechanisms of resistance to bacterial infection

In a study published in Microbes & Infection, researchers from the Infection et Immunité des Poissons team (Virologie et Immunologie Moléculaires - VIM unit, INRAE/UVSQ/UPSaclay, Jouy-en-Josas), in collaboration with INRAE's GABI and IERP units, have established a set of phenotypes linked to pathogenesis through the characterization of a collection of isogenic trout lines with contrasting resistance. Guided by the 3Rs principle, individual monitoring by non-lethal blood sampling has been applied for the first time in trout to monitor bacterial infection and host response; this approach makes it possible both to reduce the number of fish used and to increase the power of the experimental set-up.
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Article

14 September 2023

Redaction: INRAE - Edition P. Huan

Thesis offering "Genetic determinism of vaccine response and caecal microbiota composition in free-range chickens."

This thesis will contribute to the production of knowledge that will make it possible to support the change of practices, in particular in terms of integrated management of health and well-being in free-range poultry farms.
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@ Alicia Jacques
Article

05 October 2023

Redaction: A. Jacques - G. Restoux - Edition P. Huan

Reintroduction of genetic diversity in populations from frozen semen: The case of Abondance, a local French dairy cattle breed

Genetic diversity is the genetic variability between individuals in the same population or between populations. In the case of livestock, breeds are often equated with populations, and the diversity they contain is essential for their evolution and adaptation. However, breeding is about selecting the best individuals and therefore does not maintain the full diversity of animals. However, it is possible to freeze semen from bulls to preserve it and potentially use it later.
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GABI: Animal Genetics and Integrative Biology unit
Article

14 September 2023

Redaction: G. Restoux - Edition P. Huan

The local breeds of French hens: a resource to be conserved

The many local breeds of French chickens constitute an important reservoir of neutral and adaptive diversity. They are generally free-range and territory-associated, and thus potentially adapted to a wide range of environmental conditions, which can be useful for coping with global warming and making the agroecological transition.
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Article

14 September 2023

Redaction: INRAE - Edition P. Huan

Thesis offer "Hologenomic methods to account for host microbiota in genetic evaluations"

This project will contribute to establishing clear guidelines for the simulation of realistic hologenomic data, the construction of microbiota-based similarity matrices, and the optimal combination of genomic, microbiota, and multi-omics data in a wide variety of scenarios.
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Article

05 October 2023

Redaction: P. Huan, Translation W. Brand-Williams

Ekaterina Tomilina, a doctoral student at MaIAGE and GABI a finalist of the competition "My thesis in 180 seconds" at the University Paris-Saclay.

Her PhD project englobes a research project at the interface of different fields of study, since it is applied to a current biological question raised at INRAE concerning bull fertility. Her presentation was focused on copula methods for network inference of multi-omics regulation.
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INRAE
Article

05 October 2023

Redaction: GABI M. Tixier-Boichard - Edition P. Huan - translation W. Brand-Williams

A new consortium on genetic diversity of chickens: Large scale genomics to decipher the origins and adaptations of chickens

The FarmGenomic project is aimed at exploring "How the high-throughput genomic era can be used to answer our questions on the evolution of chickens?".
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Article

05 October 2023

Redaction: GABI - Edition P. Huan

Elitsa Ivanova will defend her thesis on Tuesday, March 14 (2:00 pm) in the Jacques Poly amphitheater (building 440) at the INRAE center in Jouy-en-Josas.

Her PhD dissertation entitled "The mammary gland: Role of SOCS2 in its development and impact of inflammation during successive lactations" was carried out under the supervision of Fabienne Le Provost within the GABI unit.
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INRAE
Article

05 October 2023

Redaction: INRAE - Edition P. Huan - Translation W. Brand-Williams

INRAE 2023 Engineers and Technicians Open Competition: applications until March 23

More than 250 positions are available now on the INRAE Jobs web site! Discover all the positions available and apply on-line. If you do not have the degree required to apply, you may request an equivalence. Discover the profiles open to join one of GABI's teams!
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Article

03 February 2023

Redaction: INRAE - Edition P. Huan

Open competitions for research scientists at INRAE 2023 : GABI is recruting two deux Junior Research Scientists

You would like to contribue to public research, to get involved in projects important for society's challenges ? Join our research teams by enrolling in one of our Open competitions for a Junior Research Position (men/women) : applications open up to March 2, 2023!
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Best wishes INRAE 2023
Article

14 September 2023

Redaction: INRAE

GABI wishes you all the best for 2023

Our future is being written now!
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Article

14 September 2023

Redaction: Communication GABI - P. Huan

Job offer for the European infrastructure project EuroFAANG

Would you like to join INRAE at GABI and enjoy living in France? Send your application to join the international and dynamic team of EuroFAANG! EuroFAANG is a European Infrastructure project (HORIZON-INFRA-2022-DEV-01 Research Infrastructure Concept Development) coordinated by the Research Institute for Farm Animal Biology (FBN, Germany) that will start in January 2023 and run until December 2025. We are seeking a dynamic and self-motivated Assistant Research Manager.
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INRAE
Article

05 October 2023

Redaction: F. Phocas - Edition P. Huan

Genome-wide association study and genomic prediction of tolerance to acute hypoxia in rainbow trout.

Fish are exposed to large variations in the concentration of oxygen in their aquatic environment. When oxygen is depleted in relation to what is needed to maintain the energy metabolism of fish, this is called hypoxia. Hypoxia is one of the major threats to the aquaculture sector, causing substantial economic losses for fish farmers. It can strongly affect the health and welfare of fish, impacting on growth, reproduction, behaviour, immunity and other energy-demanding activities. Thus, improving hypoxia tolerance is of great economic and ethical interest to be included in aquaculture breeding programmes.
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INRAE. Marie-Christine Lhopital, Race bovine limousine au coeur des Monts du Lyonnais (Sourcieux les Mines, Rhone)
Article

05 October 2023

Redaction: GABI - Edition P. Huan

The MYH3 gene, coding for an embryonic myosin, is mutated in a recessive form of cleft palate in Limousine cattle

Among the anomalies reported to the Observatoire National des Anomalies Bovines (ONAB, www.onab.fr), a form of cleft palate emerged in 2012 in Limousine cattle. The animals have a total cleft palate involving the bony palate and the muscular palate. In the majority of cases, no other clinical signs are associated with cleft palate. Nevertheless, the survival of the animals and their well-being are largely compromised by this anomaly.
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CC Pikist
Article

05 October 2023

Redaction: GABI - Edition P. Huan - Translation W. Brand-Williams

A promising therapeutic strategy for COVID—19 : technology of antisens oligonucleotides

The ongoing COVID-19 pandemic continues to pose a need for new and efficient therapeutic strategies. We explored antisense therapy using oligonucleotides targeting the severe acute responiratory syndrome (SARS-CoV-2). We are pleased to annouce the publication of this collaborative study involving GABI, the VIM Unit and The University Andres Bello (Santiago, Chili) on the experimental demonstration of active Antisens Oligonucleotide activity on the in vitro inhibition of SARS-CoV-2 virus replication, the virus responsible for COVID-19.
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@INRAE Bertrand Nicolas
Article

05 October 2023

Redaction: INRAE - Edition P. Huan

Genetics for sustainable aquaculture: a review of 20 years of rainbow trout breeding

While fishing has reached its limits, the demand for fish is increasing every year. In this context, aquaculture constitutes an alternative, provided that it is sustainable while allowing a quality production. INRAE, the Aqualande group and its trout selection and reproduction company "les Sources de l'Avance", and the Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF) have carried out a review of a 20-year rainbow trout selection program conducted by the company. They compared the growth and feed requirements of trout from this program with those of non-selected trout. Their results, published in Aquaculture Reports, show that 17 to 20 percent less feed is now required for the same growth of the fish with the selected trout, thus reducing the environmental impact. A locally produced sustainable feed, without fish oil, fish meal or soy, was also tested on both groups of fish. Growth gains and nutritional qualities are maintained with this feed of the future. This original work on a global scale shows that genetic improvement and innovative feed development can be effectively combined to contribute to a more sustainable aquaculture.
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Article

05 October 2023

Redaction: INRAE IMR GABI A. Rau - Edition P. Huan - Translation W. Brand-Williams

Integration of complex annotations in Bayesian genomic prediction models

Multiple, complex, overlapping annotations.... You are wondering how is the best way to use them in your genomic prediction model? The BayesRCO open software is what you need! In the H2020 GENE-SWitCH project, scientists from GABI have developed two new Genomic Evaluation (GE) Bayesian models (BayesRCπ et BayesRC+) to improve assoications between genotypes and quantitative phenotypes while managing complex annotations.
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AAF
Article

05 October 2023

Redaction: INRAE - Edition P. Huan

Two scientists from GABI were recognized during a solemn ceremony at the Frenche Academy of Agriculture

Each year, the French Academy of Agriculture awards two prizes during its annual meeting in September. This year, two scientists from GABI were recognized for their work: the GOLD MEDAL was awarded to Michèle Tixier-Boichard and the Silver-Dufrenoy medal to Ronan Griot, for his work during his PhD. The award ceremony was held on September 21st, 2022. Congratulations to them both!
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Article

05 October 2023

Redaction: M. Tixier-Boichard - Edition P. Huan

Michèle Tixier-Boichard, Director of research at INRAE, becomes the new president of the World’s Poultry Science Association (WPSA), taking over from Professor Ning Yang (China)

At the Council Meeting, held in Paris on August 9, 2022, during the XXVI World’s Poultry Conference, the position of President of the World’s Poultry Science Association was officially passed from Pr Ning Yang of China to Dr Michèle Tixier-Boichard from France.
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