You are a cellular biologist by training with an established experience in research, willing to contribute to the agro-ecological transition in farming by proposing an ambitious research project. Please contact the MoDiT team, Animal Models and Tissue Differentiation (www.jouy.inrae.fr/gabi). We are looking for a cellular biologist to decipher the molecular and cellular mechanisms (such as intracellular metabolism, intercellular exchanges…) that link some mutations to the appearance of developmental abnormalities.
Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial insemination represent a relevant model in this field, as the broad dissemination of bull semen considerably alleviates confounding factors and enables the precise assessment of male fertility. This study was therefore designed to assess the potential for sperm DNA methylation to predict bull fertility.
In an article published in the journal Biostatistics, biostatisticians from the GABI unit, in partnership with oncologists and human genomicists from the University of Wisconsin-Milwaukee and the Medical College of Wisconsin, propose a new integrative approach for the quantification and characterization of the deregulation of multi-omics regulation pathways, by calculating individualized pathway disruption scores.
The article, "Opportunities for genomic selection of cheese-making traits in Montbéliarde cows" published in the June issue of the Journal of Dairy Science was selected by the journal's Editor-in-Chief, Paul Kononoff, as the "Editor's Choice". The article will be placed on the home page of the journal for a month and will then join the "Editor's Choice" collection.
A study of the Caprine-like Generalized Hypoplasia Syndrome (SHGC) in the Montbeliard breed identified a mutation leading to the truncation of the C-Nap1 protein. In order to gain knowledge on the role of this protein, we created a murine model containing a similar mutation. The analysis of these mice did not confirm the role of this protein in the appearance of the SHGC syndrome but revealed its role in male fertility.
Within the context of a changing climate and the diversification of breeding methods, animals will be more exposed to disturbances of their environment. In order to identify indicators of resilience in animals to such disturbances, INRAE, Wageningen University (The Netherlands) and the selection company Hendrix Genetics (Belgium) analyzed data from more than 60 000 laying hens. They identified three easily-measured indicators for resilience which would be in part determined by genetic factors. These results, published on April 20th in Genetics Selection Evolution, lead to new perspectives for selection of more resilient laying hens.
Fanny presents her PhD subject aimed at improving sustainability and health conditions in animal production through studies on the functionnal genomes of pigs and chickens. Her PhD is financed by the H2020 GENE-SWITCH project and INRAE's Animal Genetics Division.
Scientists from the "Integrative Biology and Equine Genetics Teams" (BIGE) at GABI have developed a 3-SNP genotyping test that explains in part, the variance of the wither size in a population of French Saddle Poneys. This new molecular genotyping test will allow the optimization of selection of reproducers and the management of reasoned couplings.
Single Step is a genomic evaluation method that simultaneously uses all animals, whether genotyped or not, in only one step. It is a major evolution for genomic selection. This important work was done in three steps: an entirely new software was developed by INRAE (HSSGBLUP); validating studies and a comparison was done by the UMT eBIS (ASAP project); and deployment work as part of a UNIGENO project coordinated by GenEval and Idele.
PhD (or equivalent) degree in Biostatistics / Applied Mathematics / Artificial Intelligence, with excellent training in statistical learning and data science, a strong interest in modeling biological data, as well as very good programming skills (R / Python) : Apply to become a researcher !
Adapting and protecting agriculture faced with the challenges of climate change is a group reflection carried out by the Ministry of Agriculture and Food within the framework of the Varenne agricole de l'eau and adaptation to climate change. The reports and conclusions from the different working groups as well as the contribution of Animal Genetics to improve animale resilience to clmate change are available!
Laser capture microdissection to study Bacillus cereus iron homeostasis gene expression during Galleria mellonella in vivo gut colonization.
The UMR GABI wished you a beautiful and pleasant 2022. Happy new year !
The UMT eBIS was once again labelized in 2021, joining scientists and engineers from INRAE, IDELE and ALLICE in a 5-year project to produce knowledge on the characterization of the bovine genome and genetic determinism of traits and for the develoment of selection methods and tools for this species. This UMT is hosted at the GABI laboratory at Jouy-en-Josas.
On 26 November, Marc Vandeputte (GABI, Genetics and Aquaculture team) was awarded an honorary doctorate by the University of South Bohemia in the Czech Republic. Johann Verreth (Professor Emeritus at the University of Wageningen) received the same distinction on the same day.
Viruses are sometimes our ennemies but sometimes our friends. In the fight against pathogenic bacteria, they can be precious allies, eliminating bacteria when our medicines no longer work. But more importantly, they are not sources of new resistances to antibiotics in bacteria. This is the conclusion of a studied by scientists at INRAE, published on October 25, 2021 in the journal ISME Communications.
Through the genetic improvement of the rainbow trout, the efficiency of trout production over the last thirty years has increased notably. But this selection has also contributed to an increase in inbreeding, menacing genetic progress on the long term and the adaptation of populations to a changing environment. That is why scientists from the GABI unit sought to evaluate the effects of inbreeding on the reproductive performances of the rainbow trout.
Microbial ecosystems (intestinal, food, soil microbiota, ....) are continuously being recognized for their major role in many fields: amongst them, fungi frequently enter scientific debates. The new version of the FROGS software allows the precise identification of fungal communities present in the microbiota in addition to the bacterial communities identified by the previous version.
For 10 years, in dairy cattle, "classical" selection has been put aside for genomic selection. This evolution has allowed more rapid progress and a considerable reduction in the cost of selection. Since then, it has been applied to an ever increasing number of animal and plant species and has spiked interest in many others.
What are the consequences on genetic evolution of an Apis melifera bee population undergoing selection?
The kick-off of the H2020 SCALA-MEDI project included 17 European partners for the launching of this project whose objective is the improvement of the sustainability and the quality of ovine and poultry production via the development of the adaptation potential of local breeds in the MEDIterranean area.