News

05 October 2023

By: INRAE IMR GABI A. Rau - Edition P. Huan - Translation W. Brand-Williams

Integration of complex annotations in Bayesian genomic prediction models

Multiple, complex, overlapping annotations.... You are wondering how is the best way to use them in your genomic prediction model? The BayesRCO open software is what you need! In the H2020 GENE-SWitCH project, scientists from GABI have developed two new Genomic Evaluation (GE) Bayesian models (BayesRCπ et BayesRC+) to improve assoications between genotypes and quantitative phenotypes while managing complex annotations.
AAF

05 October 2023

By: INRAE - Edition P. Huan

Two scientists from GABI were recognized during a solemn ceremony at the Frenche Academy of Agriculture

Each year, the French Academy of Agriculture awards two prizes during its annual meeting in September. This year, two scientists from GABI were recognized for their work: the GOLD MEDAL was awarded to Michèle Tixier-Boichard and the Silver-Dufrenoy medal to Ronan Griot, for his work during his PhD. The award ceremony was held on September 21st, 2022. Congratulations to them both!

05 October 2023

By: M. Tixier-Boichard - Edition P. Huan

Michèle Tixier-Boichard, Director of research at INRAE, becomes the new president of the World’s Poultry Science Association (WPSA), taking over from Professor Ning Yang (China)

At the Council Meeting, held in Paris on August 9, 2022, during the XXVI World’s Poultry Conference, the position of President of the World’s Poultry Science Association was officially passed from Pr Ning Yang of China to Dr Michèle Tixier-Boichard from France.

05 October 2023

By: GABI - E. Barrey - Edition P. Huan

The therapeutic potential of RNA transcripts: Role of mitochondria-associated non-coding RNAs in intracellular communication

This research theme aims to gather knowledge on the role of non-coding RNAs (ncRNAs) that participate in the communication pathways between mitochondria and the cell. This special issue of Frontiers in Physiology presents unique research focused on mitochondria-associated ncRNAs as well as original papers demonstrating the therapeutic potential of certain RNAs. BIGE researchers are actively involved in the scientific work in this area.
@INRAE M. Dupont-Nivet

05 October 2023

By: GABI - Edition P. Huan

A powerful new tool for identifying genes of interest in farmed fish: a high-density chip with 665,000 genetic markers for rainbow trout

The knowledge of the variations of the DNA sequence which constitutes the genome of an individual is a central information in genetic research. If it is possible to sequence the entire genome to know all these variations, it remains very expensive. Genotyping chips, which are much less expensive, make it possible to work with an intermediate density of information (corresponding to a selection of positions, or "markers", judiciously distributed over the genome). However, their efficiency is directly related to the number of available markers. For rainbow trout, the leading farmed fish species in France, INRAE and its partners have just developed a new high-density genotyping chip (665,000 markers, i.e. about 15 times more than the best tools available so far), which greatly increases the analysis power obtained. By providing access to much more precise genomic information, this chip will make it easier to identify the genes responsible for differences between individuals and to develop more effective selection procedures to adapt animals to changing environmental conditions.
GABI: Animal Genetics and Integrative Biology unit

14 September 2023

By: GABI - Edition P. Huan

The composition of the caecal microbiota of laying hens infected with IBV varies according to genetic lineage and vaccination status

Vaccination of livestock is one of the most effective ways to prevent infectious diseases. The links between vaccine response and variations in the gut microbiota are poorly studied, yet the latter plays a considerable role in the regulation of immunity. In addition, it has been established that genetic variations in hens can influence the composition of the microbiota and the vaccine response.

09 October 2023

By: GABI - Edition P. Huan

INRAE annual mobility campaign: discover the positions open at GABI!

You are an INRAE employee or, more generally, a civil servant or have a permanent contract under public law in one of the three civil services (with at least 3 years' seniority). Do you want to evolve in your missions and take up new challenges? With us, you will develop useful and beautiful research projects.
INRAE_Brice_Mosa_CA-SYS

05 October 2023

By: GABI - Edition P. Huan

A research agenda for scaling up agroecology in European countries

A profound transformation of agricultural production methods has become unavoidable due to the increase in the world’s population, and environmental and climatic challenges. Agroecology is now recognized as a challenging model for agricultural systems, promoting their diversification and adaptation to environmental and socio-economic contexts, with consequences for the entire agri-food system and the development of rural and urban areas. Through a prospective exercise performed at a large interdisciplinary institute, INRAE, a research agenda for agroecology was built that filled a gap through its ambition and interdisciplinarity.

14 September 2023

By: GABI - Edition P. Huan

Are you a cellular biologist? INRAE is hiring a junior scientist on a research project in cellular and molecular biology!

You are a cellular biologist by training with an established experience in research, willing to contribute to the agro-ecological transition in farming by proposing an ambitious research project. Please contact the MoDiT team, Animal Models and Tissue Differentiation (www.jouy.inrae.fr/gabi). We are looking for a cellular biologist to decipher the molecular and cellular mechanisms (such as intracellular metabolism, intercellular exchanges…) that link some mutations to the appearance of developmental abnormalities.

05 October 2023

By: GABI - Edition P. Huan

Predicting male fertility from sperm methylome: application to 120 bulls with hundreds of artificial insemination records

Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial insemination represent a relevant model in this field, as the broad dissemination of bull semen considerably alleviates confounding factors and enables the precise assessment of male fertility. This study was therefore designed to assess the potential for sperm DNA methylation to predict bull fertility.

05 October 2023

By: GABI - Edition P. Huan - Translation W. Brand-Williams

Entering into the multiverse: using multiple factor analysis to characterize individualized multi-omic regulation pathways

In an article published in the journal Biostatistics, biostatisticians from the GABI unit, in partnership with oncologists and human genomicists from the University of Wisconsin-Milwaukee and the Medical College of Wisconsin, propose a new integrative approach for the quantification and characterization of the deregulation of multi-omics regulation pathways, by calculating individualized pathway disruption scores.
GABI: Animal Genetics and Integrative Biology unit

14 September 2023

By: M-P. Sanchez - Edition P. Huan - Translation W. Brand-Williams

A G2B team publication selected as the « Editor’s Choice » by the Editor-in-Chief of JDS

The article, "Opportunities for genomic selection of cheese-making traits in Montbéliarde cows" published in the June issue of the Journal of Dairy Science was selected by the journal's Editor-in-Chief, Paul Kononoff, as the "Editor's Choice". The article will be placed on the home page of the journal for a month and will then join the "Editor's Choice" collection.
@INRAE - Sandrine Floriot (Impact de la troncation de la protéine C-Nap1 Bovin vs Murin)

05 October 2023

By: GABI S. Floriot - Edition P. Huan - Translation W. Brand-Williams

C-Nap1, from the cow to the mouse, a centriolar protein gradually reveals its secrets

A study of the Caprine-like Generalized Hypoplasia Syndrome (SHGC) in the Montbeliard breed identified a mutation leading to the truncation of the C-Nap1 protein. In order to gain knowledge on the role of this protein, we created a murine model containing a similar mutation. The analysis of these mice did not confirm the role of this protein in the appearance of the SHGC syndrome but revealed its role in male fertility.
Pixabay

05 October 2023

By: INRAE - Edition P. Huan - Translation W. Brand-Williams

Discovering indicators of heritable resilience in laying hens

Within the context of a changing climate and the diversification of breeding methods, animals will be more exposed to disturbances of their environment. In order to identify indicators of resilience in animals to such disturbances, INRAE, Wageningen University (The Netherlands) and the selection company Hendrix Genetics (Belgium) analyzed data from more than 60 000 laying hens. They identified three easily-measured indicators for resilience which would be in part determined by genetic factors. These results, published on April 20th in Genetics Selection Evolution, lead to new perspectives for selection of more resilient laying hens.
INRAE F. Mollandin

05 October 2023

By: GABI - Edition P. Huan - Tranlsation W. Brand-Williams

An interview with Fanny Mollandin, a PhD student at GABI

Fanny presents her PhD subject aimed at improving sustainability and health conditions in animal production through studies on the functionnal genomes of pigs and chickens. Her PhD is financed by the H2020 GENE-SWITCH project and INRAE's Animal Genetics Division.
INRAE @Sophie Pollet

05 October 2023

By: INRA GABI - Edition P. Huan - Translation W. Brand-Williams

A new molecular genotyping test for selection of sports poneys breeders

Scientists from the "Integrative Biology and Equine Genetics Teams" (BIGE) at GABI have developed a 3-SNP genotyping test that explains in part, the variance of the wither size in a population of French Saddle Poneys. This new molecular genotyping test will allow the optimization of selection of reproducers and the management of reasoned couplings.
@INRAE D. Boichard

05 October 2023

By: GABI D. Boichard - Edition P. Huan - Translation W. Brand-Williams

Publication of dairy catlle indexes estimated with the "Single Step" method

Single Step is a genomic evaluation method that simultaneously uses all animals, whether genotyped or not, in only one step. It is a major evolution for genomic selection. This important work was done in three steps: an entirely new software was developed by INRAE (HSSGBLUP); validating studies and a comparison was done by the UMT eBIS (ASAP project); and deployment work as part of a UNIGENO project coordinated by GenEval and Idele.

14 September 2023

By: INRAE - Edition P. Huan

INRAE 2022 open competition: GABI is recruiting Junior Research Scientist in statistical learning and artificial intelligence

PhD (or equivalent) degree in Biostatistics / Applied Mathematics / Artificial Intelligence, with excellent training in statistical learning and data science, a strong interest in modeling biological data, as well as very good programming skills (R / Python) : Apply to become a researcher !
@ http://agriculture.gouv.fr

05 October 2023

By: GABI - Edtiion P. Huan - Translation W. Brand-Williams

What contribution can genetic selection make for the adaptation of agriculture to climate change?

Adapting and protecting agriculture faced with the challenges of climate change is a group reflection carried out by the Ministry of Agriculture and Food within the framework of the Varenne agricole de l'eau and adaptation to climate change. The reports and conclusions from the different working groups as well as the contribution of Animal Genetics to improve animale resilience to clmate change are available!
GABI: Animal Genetics and Integrative Biology unit

14 September 2023

By: GABI - Edition P. Huan

Laser microdissection allows fine in situ analysis of the interaction between extracellular bacteria and the host

Laser capture microdissection to study Bacillus cereus iron homeostasis gene expression during Galleria mellonella in vivo gut colonization.

14 September 2023

By: GABI - Edition P. Huan - Translation W. Brand-Williams

On our way for 2022 !

The UMR GABI wished you a beautiful and pleasant 2022. Happy new year !