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INRAE UMR 1313 Génétique Animale et Biologie Intégrative
Domaine de Vilvert, Bat 440, 78352 Jouy en Josas
Tel : +33 (0) 1 34 65 25 69
Email : fabienne.le-provost(at)inrae.fr
ORCID : 0000-0002-0588-5333

Research Team: leader of the Mammary Gland and Lactation Team (GaLac)

Diplômes

• Nov 2010  HDR (accreditation for directing research). Université Versailles-Saint Quentin.
• Mai 2004   Animal experimentation certification Level I. Ecole Nationale Vétérinaire, Maisons-Alfort.
• 1991-1995 PhD in Developmental molecular and cellular biology. Université Paris XI, Orsay.

Career at INRAE

1995 Junior research scientist (2^nd class)

        Biochemical Genetics and Cytogenetics Laboratory (INRA, Jouy-en-Josas).

2000-2001 Long-term mission

        Laboratory Physiology and Genetics (NIH, Bethesda, USA).

2002-2011 Junior research scientist (1^st class)

        Biochemical Genetics and Cytogenetics Laboratory (2002-2009),  

        UMR 1313 Animal Genetics and Integrative Biology Laboratory (since 2010) (INRA, Jouy-en-Josas).

Since 2012 Senior research scientist (2nd class)

        UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas).

Team leadership Functions

2003-2008 Leader of the "gene to phenotype" team,

        Biochemical Genetics and Cytogenetics Laboratory (INRA, Jouy-en-Josas).

2009-2013 Leader of the "Cell differentiation and specialization team" (DISC),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRA, Jouy-en-Josas).

Since 2014 Leader of the « Mammary Gland Functional Genomics and Physiology Team» (GFP-GM),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas). (https://www.jouy.inra.fr/gabi/les-Recherches/Equipes-de-recherche/GFP-GM)

Since 2019 Leader of the "Mammary Gland and Lactation Team" (GaLac),

       UMR 1313 Animal Genetics and Integrative Biology Laboratory (INRAE, Jouy-en-Josas).(/Les-Recherches/Equipes-de-recherche/GaLac)

Contribution to research collectives

2008-2012   Elected member of the Scientific Steering Committee of the INRA Jouy-en-Josas research center.

Since 2016 Appointed member of the INRA Jouy-en-Josas research center council.

Since 2011 Elected member of the INRA Animal Genetics Division Scientific steering committee.

Since 2015 Member of the Plant and Animal Genetics Specialized Scientific Commission.

2011-2015 Leader of the microARN Club, INRA CEnter, Jouy-en-Josas. (http://www.jouy.inra.fr/gabi/les-Recherches/Le-club-microARN).

Recent Publications

ORCID : 0000-0002-0588-5333

2017

Leroux C., Milenkovic D., Mobuchon L., Le Guillou S., Faulconnier Y., German B. and Le Provost F. Nutritional Regulation of Mammary miRNome: Implications for Human Studies. In: Patel V., Preedy V. (eds) Handbook of Nutrition, Diet, and Epigenetics.2017. 1-17. Springer, Cham

Mobuchon L, Le Guillou S, Marthey S, Laubier J, Laloë D, Bes S, Le Provost F, Leroux C (2017) Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland. PLoS One. 12:e0185511.

2016

Chadi S., Polyte J., Lefevre L., Castille J., Ehanno A., Laubier J., Jaffrézic F., Le Provost F (2016) Phenotypic and molecular alterations in the mammary tissue of R-spondin1 knock-out mice during pregnancy. PLoS One 9:e0162566.

2015

Laubier J, Castille J, Le Guillou S, Le Provost F (2015) No effect of an elevated miR-30b level in mouse milk on its level in pup tissues. RNA Biology 12:26-9. doi: 10.1080/15476286.2015.1017212.

Mobuchon L, Marthey S, Le Guillou S, Laloë D, Le Provost F, Leroux C (2015a) Food Deprivation Affects the miRNome in the Lactating Goat Mammary Gland. PLoS One 16:e0140111.

Mobuchon L, Marthey S, Boussaha M, Le Guillou S, Leroux C, Le Provost F (2015b) Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches. BMC Genomics. 16:285.

2014

Baco M, Chu CY, Bouet S, Rogel-Gaillard C, Bourneuf E, Le Provost F, Chu CY, Vincent-Naulleau S (2014) Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs. Pigment Cell Melanoma Res. 27:668-70.

Le Guillou S, Marthey S, Laloë D, Laubier J, Mobuchon L, Leroux C, Le Provost F (2014) Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes. PLoS One 9:e91938.

2013

Doridot L, Passet B, Méhats C, Rigourd V, Barbaux S, Ducat A, Mondon F, Vilotte M, Castille J, Breuiller-Fouché M, Daniel N, Le Provost F, Bauchet AL, Baudrie V, Hertig A, Buffat C, Simeoni U, Germain G, Vilotte JL, Vaiman D (2013) Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Hypertension. 61:662-8.

Leroux C, Bernard L, Dessauge F, Le Provost F, Martin P (2013) The function of lactation : regulation of biosynthesis of milk components. INRA Prod Anim. 26:117-128.

Current main scientific projects

v  ANR ReidSOCS 2016-2020: Robustness, efficiency, inflammation and diseases under the control of SOCS-2.

v  CASDAR-RT BioMarq’Lait 2018-2021: Identification dans le lait de biomarqueurs pour le monitoring du statut nutritionnel de la vache laitière.

v  Métaprogramme GISA: LongHealth 2017-2019 Integrated management of ruminant health for a sustainable dairy production.

v  Apis-Gene NutrimiRMa 2013-2015: Nutritional regulation of mammary gland microRNA in ruminants and their impact on the biosynthesis of milk components.

v  Apis-Gene miRQTLait 2017-2019: Search for associations between microRNA, genetic variants and dairy QTL.